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Precautions Prior to taking vitamin B12, tell the physician that you have: A cold or an allergy that affects your nasal cavity and the signs you develop A kidney disease A liver disease Any kind of infection An iron deficiency A folic acid deficiency An allergy to vitamin B12 or cobalt A lebers disease as cyanocobalamin can trigger optical nerve damage and blindness A pregnancy, a plan to get pregnant or a breastfeeding baby.

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Severe reactions are rare but may occur in individuals with sensitivity to cobalamin injections or high-dose supplements

One hundred fifty three (153) patients were exposed to Reclast administered once annually with a 5 mg dose in 100 mL infused over 15 minutes for up to a total of two doses, and 148 patients were exposed to a commercially-available oral weekly bisphosphonate (active control) for up to two years