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Compared to humans and mice, rats have a higher basal level of antioxidant defense gene expression, and rats have a greater capacity to respond to cellular stress, which makes them generally more resistant to drug toxicity [127]

Sensitive analysis and pharmacokinetic study of the isomers paeoniflorin and albiflorin after oral administration of Total Glucosides f White Paeony Capsule in rats

We have previously discovered that combinations of BBB nutrient transporter ligands alanine and glutathione (A-GSH), increase the permeability of vesicular and polypeptide nanocarriers containing model cargo across the BBB