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Description

In clinical studies, participants saw up to 28.7 % average body-weight reduction in the latest Phase 3 trial the highest ever reported

Some users describe a brief sharp pain during needle insertion followed by a deeper burning sensation as the medication disperses under the skin

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It is the only known circulating orexigenic hormone and signals both on vagal afferents and in the arcuate nucleus where it powerfully enhances NPY orexigenic signaling (176, 177)