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Audesse AJ, Dhakal S, Hassell L-A, Gardell Z, Nemtsova Y, Webb AE

Among these changes, TGF- is the most important

Adhesions can also obliterate normal pelvic angles and induce abnormal uterine flexion, while nodularity and thickening of pelvic ligaments (uterosacral ligaments) with fibrotic reactions further disrupt pelvic anatomy ( Mechanically, these changes impair fertility through multiple pathways: extensive adhesions can occlude the tubal ostium and embed ovaries, blocking sperm passage and oocyte release

Med Principles Pract J 2:14 Wu Q, Yang Z, Nie Y et al (2014) Multi-drug resistance in cancer chemotherapeutics: mechanisms and lab approaches