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de Vogel S, Wouters KA, Gottschalk RW, van Schooten FJ, de Goeij AF, de Bruine AP, Goldbohm RA, van den Brandt PA, Weijenberg MP, van Engeland M

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Importantly, this quiescent or slow-cycling state remains reversible: upon drug withdrawal or relief of selective pressure, DTP cells can rapidly re-enter the cell cycle and restore proliferative capacity, clearly distinguishing them from senescent cells or terminally arrested populations that display stable growth arrest and irreversible phenotypic commitment ( The third central mechanism involves chromatin remodeling and epigenetic plasticity