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Certain factors are known to decrease LES tone or increase intra-abdominal pressure, contributing to acid-gastric reflux

evaluated stress levels in patients with PG using the Perceived Stress Scale (PSS) and found significantly higher stress scores in patients with PG vs controls.20 Zhang et al

Morisco, C., Zebrowski, D

However, important challenges persist, including off-target effects, immunogenicity, and potential risks and ethical issues in their application for pregnant or lactating women