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A Systematic Review of Randomised Clinical Trials

Wei et al (146) discovered that HKL suppresses BNIP3, NIX and FUNDC1 expression and reduces AMPK activation levels in CKD models, resulting in the reduction of excessive mitophagy and induction of protective effects on the kidneys

Molecules derived due to persistent excessive FFAs and glucose in plasma are considered to become metabolic-associated molecular patterns or so-called DAMPs for innate immune response mediated metaflammation [240, 241]