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The inhibitory effects of chronic exposure of vitamin B12 on glutamate-induced neurotoxicity were determined in cell culture, probably by altering the membrane properties through S-adenosylmethionine (SAM)-mediated methylation [26, 27]

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You reach 2.5 mg in four weeks instead of starting there on day one, and by the time you hit 5 mg at week five, your body has experienced a month of gradually increasing receptor activation

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Rumora A.E., Savelieff M.G., Sakowski S.A., Feldman E.L