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Step 5: Maintain this routine daily for at least three months to evaluate the results

Females are twice as likely to receive MS as males [3]

The here described methodology extends the currently available methods for cumbersome preparation of bioconjugation-ready oligonucleotides, which mainly rely on synthesis of heterobifunctional linkers followed by NHS- or phosphoramidite-mediated ON modification

In particular, NO produced by inducible nitric oxide synthase (iNOS) exerts a bacteriostatic effect on Mtb by inhibiting respiration 1 and is crucial for protection against TB 2,3