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The second involved the synthesis of nonpeptidic substances with the ability of directly blocking the GnRH receptor (GnRHR)

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Estrogenic activities of di-2-ethylhexyl phthalate

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If the same vial were diluted with 4mL of water, the concentration would be halved to 2,500mcg/mL, and the same 2,500mcg dose would now require 1mL, or 100 units

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FIGURE 4-7 The beaker on the left represents a low Vd drug that is mainly distributed to the extracellular fluid

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