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12 The decrease in estrogen levels experienced during menopause influence the entire nervous system, leading to a potential increase in physical symptoms such as hot flashes as well as psychological symptoms, such as increased stress and anxiety

Table 8: Adverse Reaction in 2% or More of ARISTADA-Treated Patients and That Occurred at Greater Incidence than in the Placebo-Treated Patients in the 12-Week, Placebo-Controlled, Fixed-Dose Schizophrenia Trial In an open label pharmacokinetic study, the adverse reactions associated with the use of 441 mg monthly, 882 mg every 6 weeks, and 1064 mg every 2 months were similar across the dose groups

Similarly, the use of supplemental tryptophan has caused eosinophilia-myalgia syndrome, which shares features with nephrogenic systemic fibrosis, including chronic indurated skin, neuropathy, and myopathy

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