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Recently, GPX3 has been recognized as a novel regulator of insulin receptor expression, insulin receptor and GPX3 expression were positively correlated in mouse models of obesity and insulin resistance: By activating the transcription factor SP1, GPX3 promotes insulin receptor expression in 3T3-L1 preadipocytes and improves adipose tissue insulin sensitivity

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It also plays a central role in liver detoxification, immune system regulation, protein synthesis, and the recycling of other antioxidants including vitamins C and E

Other research supports its ability to reduce nerve compression