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doi:10.1016/j.biortech.2011.12.030 Wang F, Dong K, Chen X, Zhu X (2013a) Yeast engineering bacterial strain capable of producing glutathione and application thereof to production of glutathione

[37] observed that methotrexate (MTX), a chemotherapy drug known for its severe cardiac side effects, induced alterations in the cardiac histopathology and enhanced the caspase-3 expression in the rat cardiac tissues, indicating the exacerbation of cardiomyocyte apoptosis