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Replacing the bromine with a hydroxyl group (ENDO13) and introducing a phenylacetamide (ENDO11) at the diethylamino end of ENDO3 did not result in activity improvement (Fig

The enzymatic activity of Grx1 and Grx2 were observed to increase in cell lysates treated with OH Py 2 N 2 (1100 m) in a dose-dependently manner (Figure 4B) along with the protein levels of Grx1 and Grx2 (Figure 4A)

Additionally, some mechanistic inferences are based on observational data of metabolite levels or single-gene regulation, lacking causal validation via interventional experiments

The tissue was fixed in TEM fixative containing 2% glutaraldehyde and 2% formaldehyde in 0.1 M cacodylate buffer (pH 7.3) for 48 h, then washed with 0.1 M cacodylate buffer (pH 7.3)