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107-109 It is hoped that the CLEVER study will definitively establish the most appropriate and effective therapy for patients with aortoiliac disease

Previous research has shown that immuno-metabolic dysregulations map more consistently to symptoms of the atypical spectrum characterized by altered energy intake/output (in particular the reversed neurovegetative symptoms of hyperphagia, hypersomnia with leaden paralysis and fatigue) [2] and symptoms of anhedonia [33]