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The emergence and selection of SIM are supported by studies of bacterial populations, in which reversible hypermutable phenotypes, sometimes in small-cell subpopulations, have the advantage of increasing population diversity without the drawback of continued accumulation of potentially dangerous mutations once cells adapt and exit stress 182,183

Numerous therapies directed at specific targets have been suggested, some of which have yet to undergo clinical assessment

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As used herein, therapeutically regulating skin condition includes ameliorating, e.g., diminishing, minimizing and/or effacing, discontinuities in skin, including signs of skin aging