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More visible whitening and even skin tone results typically appear within 4 to 6 weeks, while best results are achieved after 6 to 8 weeks of regular use

Oxford, England: Oxford University Press, 1998

We summarize key biochemical control nodes governing NET generation and persistenceoxidant signaling, calcium-dependent chromatin remodeling, protease-oxidase feed-forward loops, and plateletendothelial crosstalk that promotes intravascular NET deposition