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In most clinical trials, zero patients stopped therapy solely because of local reactions

Cerulenin induces apoptosis in CRC cell lines and has been shown to reduce liver metastasis when used in combination with oxaliplatin [210, 211]

doi: 10.1007/s00421-019-04234-2

Multiple observational studies have found that individuals with low B12 are significantly more likely to report depressive symptoms, and intervention studies show that correcting the deficiency improves mood outcomes sometimes substantially