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In the present study, we examined changes in glucose metabolism in a mouse systemically harboring a loss of function mutation in Insr (a single amino acid substitution from proline to leucine at 1195 amino acid residue (P1195L)), which has been shown to act as a dominant-negative mutant in heterozygosity 6

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If fatigue continues, a clinician may evaluate anemia, thyroid disease, sleep problems, medication effects, mood concerns, or other causes