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Overview of disorders of flavocoenzymes and flavoproteins associated with primary and secondary mitochondrial dysfunction Primary disorders of flavocoenzyme metabolism associated with mitochondrial dysfunction Disorder of Riboflavin Transport Riboflavin Transporter Deficiency Neuronopathy (OMIM #614707, OMIM# 211500, and OMIM #211530) previously known as Brown-Vialetto-Van Laere and Fazio- Londe syndrome Human riboflavin transporters, RFVT1, RFVT2, and RFVT3, are encoded by their respective genes, SLC52A1 , SLC52A2 , and SLC52A3 [18-21]

Jiang H, Wang GT, Wang Z, et al

Currently, there is no approved effective treatment for the disease, leading to an increasing socioeconomic burden and a serious impact on the quality of life of patients (203, 204)

GST is also a commonly used solubility tag, meaning it is added N-terminally to another protein to help keep it soluble (Figure 2)