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et al, Homocysteine as a risk factor for vascular disease

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Qin Z, Du T, Zheng Y, Luo P, Zhang J, Xie M, et al

Upon ligand binding, PPAR-alpha undergoes a conformational change and associates with the nuclear receptor of 9- cis retinoic acid (RXR), forming a heterodimer that binds to PPAR-alpha responsive elements in the promoter of multiple genes associated with fatty acid metabolism, such as CPT1 (beta-oxidation), DECR2 (unsaturated fatty acid synthesis), ACAA1 (peroxisomal fatty acid oxidation) and ACADVL (beta-oxidation of very-long chain fatty acids) [23]