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The GLU hypothesis of schizophrenia 4 grew out of the observation that phencyclidine, a drug of abuse that is a potent NMDA antagonist (50-fold stronger than ketamine), can trigger in healthy individuals a severe psychosis indistinguishable from schizophrenia, with positive and negative symptoms, cognitive impairment, thought disorder, catatonia, and agitation

For example, mouse studies on the gutbrain axis have been pivotal in uncovering the role of SCFAs in microbiotagutbrain signaling

Bezerra DS, de Araujo KF, Azevedo GM, Dimenstein R

[4] The most common clinical manifestation of psoriasis is cutaneous lesions or plaques