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Description

Most patients begin to notice subtle changes within 2 to 4 weeks

In the context of the present invention, pharmaceutical activity encompasses prophylactic and therapeutic activities

Transcriptomics analysis of Sox9 mutant mice showed that deletion of Sox9 resulted in progressive disc degeneration and alterations in ECM organization indicating that Sox9 expression can also directly impact disc cell survival and ECM maintenance (Tsingas et al., 2020)