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It is important to note that a decrease in the degradation rate of autophagy substrates, caused by reduced lysosomal function due to endoplasmic reticulum stress, can weaken the overall autophagy process

Causes of Night Sweat While sweating is a normal response to overheating, it may sometimes occur because of issues such as hot climate or exercise

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Particularly in tumor cells with active glycolysis, accumulated lactate stabilizes and increases the activity of proglycolytic transcription factors such as HIF-1 and c-Myc, as well as the expression of their downstream target genes, via lactylation, thereby forming a self-reinforcing positive feedback loop that further entrenches the glycolytic phenotype of tumors [78, 79]