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Donlan AN, Sutherland TE, Marie C, Preissner S, Bradley BT, Carpenter RM, et al

Genetic induction of ferroptosis in a small fraction of K14 + KCs in mouse epidermis via the deletion of Gpx4 was sufficient to initiate and maintain a phenotype with cutaneous and systemic inflammation closely resembling psoriasis, and to activate canonical signaling pathways and multiomics biomarkers linked to the disease