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doi: 10.1371/journal.pone.0143128 112 LivanosP.ApostolakosP.GalatisB

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These byproducts, traditionally viewed as mere hallmarks of oxidative damage, act as DAMPs that can modulate the phenotype and function of surrounding immune cells, particularly macrophages and dendritic cells (DCs) ( Importantly, the immunological consequences of ferroptosis are highly context-dependent, demonstrating a dual-edged nature that may either stimulate or suppress anti-tumor immunity

Figure 4A illustrates the experimental setup, where 5 10 3 luc-Molm13 cells were injected into NSG mice via tail vein