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Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)

This in turn stimulates the liver to produce insulin-like growth factor-1 (IGF-1), which mediates many of the anabolic and metabolic effects associated with human growth hormone

Bryan Johnson currently serves on the Board of Directors for several non-profits and is a former Board Member of Baltimore Mental Health Systems Inc

Interestingly, while BPC-157 promotes healing-associated angiogenesis, research also demonstrates it can inhibit tumor-promoting effects of VEGF signaling via the MAPK pathway in melanoma cell lines, suggesting context-dependent modulation of vascular growth that may preferentially support physiological tissue repair over pathological neovascularization