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This ratio can be altered by increased levels of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS), or a decrease in antioxidant defense mechanisms [24]

For instance, the release of Smac/Diablo into the cytosol ensures the efficiency of caspase 3 in proteolyzing target proteins through inhibition of inhibitor of apoptosis proteins (IAPs)

It plays a major role in the human redox defense system as it has the highest quenching ability against singlet oxygen, a high-energy form of oxygen.[69] Lycopene is detected at high concentrations in human testes and seminal plasma with levels that tend to be lower in men suffering from infertility.[70] Gupta and Kumar investigated oral lycopene therapy in 30 men with iOAT, who were given 2 mg of lycopene twice daily for 3 months.[31] The authors reported statistically significant improvements in sperm concentration and motility in 66% and 53% of patients, respectively

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