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De Marco A, Ferrer-Miralles N, Garcia-Fruits E, Mitraki A, Peternel S, Rinas U, Trujillo-Roldn MA, Valdez-Cruz NA, Vzquez E, Villaverde A

These changes occurred before the increase in THDA levels, indicating that the loss of BDNF-TrkB signalling and upregulation of GSTO2 happens before the hyperdopaminergic state, as with the Trkb Penk -KO mice, supporting that GSTO2 increase is more likely a cause of neurodegeneration than a consequence of it

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Sublingual administration of the extract significantly increased blood flow in both normal and ischemic conditions without altering systemic blood pressure or intraocular pressure, suggesting localized vascular effects