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In addition, the involvement of the SIRT1/PGC-1 pathway in the protective effects of antioxidants against DN is also evident in studies involving nicotinamide mononucleotide (NMN)

Acta 44 KennyE

This metabolic shift enables MDSCs to sustainably generate energy in hypoxic environments, while concurrently mitigating ROS production and subsequent apoptosis, thereby safeguarding their survival and functionality (110, 112).Chiu et al