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Early life advantages from senescence partly by curtailing the proliferation of cancerous or damaged cells, promoting wound healing, and maintaining tissue homeostasis.32 The senescence-associated secretory phenotype (SASP) comprises bioactive substances generated by senescent cells that modify immune responses and tissue repair

Polyunsaturated fatty acids (PUFAs), which serve as the main substrates for lipid peroxidation, require esterification and incorporation into membrane phospholipidsespecially polyunsaturated fatty acid-phosphatidylethanolamine (PUFA-PE)to participate in ferroptosis signaling processes ( Fe 2+ within cells generates hydroxyl radicals (OH) through the Fenton reaction, thereby initiating the peroxidation of PUFAs ( - -GSH-GPX4 axis

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Chen J, Jiang X, Carroll S, Huang J, Wang J