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Impaired autophagy, oxidative stress, and reactive oxygen species Accumulation of Gb3 in lysosomes interferes with the autophagic process (14, 76), leading to the accumulation of damaged organelles including mitochondria (77) and protein aggregates, triggering inflammation

High voltage (2000 V) was applied to low volume Titanium union (Valco) and the tip positioned ~5 mm from the heated capillary ( T = 275 C) of an Orbitrap Fusion Lumos (Thermo Electron, Bremen, Germany) mass spectrometer

This presents additional health-related benefits, particularly since obesity is associated with impaired immune function, along with a host of other health problems

[DOI] [PubMed] [Google Scholar] 66.Oyono-Enguelle S., Freund H., Ott C., Gartner M., Heitz A., Marbach J., Maccari F., Frey A., Bigot H., Bach A.C