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The core goal of metabolic intervention is to eliminate metabolic barriers in the TME, establishing favorable conditions for the survival and functional performance of effector immune cells (particularly CD8 + T cells) while concurrently attenuating the activity of immunosuppressive populations (e.g., Tregs and MDSCs)

Contraindication(s) Since oral administration of acetylcysteine may result in vomiting or aggravate vomiting associated with acetaminophen overdosage, patients at risk of gastric hemorrhage (e.g., those with esophageal varices or peptic ulcers) should be evaluated with regard to the relative risks of upper GI hemorrhage and acetaminophen-induced hepatotoxicity and treatment with acetylcysteine given accordingly

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