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6.1.2.3 Pharmacodynamic findings Further pharmacodynamic analysis evaluated brensocatibs inhibitory effects on different NSPs ( 6.1.3 ASPEN study (phase III clinical trial) 6.1.3.1 Study design and scope Based on positive results from the WILLOW study, Insmed initiated the large-scale Phase III ASPEN clinical trial to further validate brensocatibs long-term efficacy and safety ( 6.1.3.2 Primary efficacy results The ASPEN trial enrolled 1,721 patients across 35 countries to evaluate brensocatibs effectiveness in bronchiectasis management

The ionization state of these side chains affects the physical and chemical properties of proteins and is important for their interactions with other proteins, substrates or ligands, and other macromolecules as well as for their physiological functions