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108Xeljanz (tofacitinib): Initial clinical trial results of increased risk of major adverse cardiovascular events and malignancies (excluding NMSC) with use of tofacitinib relative to TNF-alpha inhibitors

The patient population belonged to diverse ethnic backgrounds, reflecting the global prevalence of IGS, notably in Scandinavian and Mediterranean regions, the former primarily due to CUBN [1,2,3,4] gene variant, and the latter often attributed to AMN variants secondary to consanguinity

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