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It was found that gastrodin could reduce blood pressure in spontaneously hypertensive rats, and its mechanism may be related to the direct reduction of Ang level or indirect inhibition of the RAAS by activating peroxisome proliferator-activated receptor (PPAR) ( Table 6 TCM preventing and treating upstream AF targets on RAAS

Med Chem 13(5):477483 Yagoda N et al (2007) RASRAFMEK-dependent oxidative cell death involving voltage-dependent anion channels

10.1016/j.abb.2007.04.015 Arch