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Global J Biochemistry 2

doi: 10.1016/j.it.2022.01.007 32

These stressors result in the release of mitochondrial danger signals such as cardiolipin and mtDNA, as well as an excess of mitochondrial reactive oxygen species (mtROS)

While topical use is typically considered safe during pregnancy, many products marketed for "skin brightening" contain other ingredients like hydroquinone or high-strength retinoids, which are often advised against during pregnancy