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Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG , O'Neil RG, McConkey DJ

The participants were divided into the following experimental groups or a placebo group: 1 mg of retatrutide (subcutaneously) 4 mg of retatrutide (subcutaneously), starting at an initial dose of 2 mg 4 mg of retatrutide (subcutaneously), starting at an initial dose of 4 mg 8 mg of retatrutide (subcutaneously), starting at an initial dose of 2 mg 8 mg of retatrutide (subcutaneously), starting at an initial dose of 4 mg 12 mg of retatrutide (subcutaneously), starting at an initial dose of 2 mg Here are the detailed results of the trial at 24 weeks and 48 weeks: Phase II clinical trial projects promising results of retatrutide in weight management

Upregulation of RAGE also induces oxidative stress (an important hallmark of neurodegeneration) via activation of NOX (fifth pathway) and downregulation of several antioxidant enzymes (sixth pathway)