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It is believed that chelation therapy may alter plaque morphology and volume, or improve endothelial function, and suggest that it might replace coronary artery bypass draft surgery [13]

Glossary 6MWD 6-min walk distance 3-NT 3-nitrotyrosine AEC alveolar epithelial cells ARE antioxidant response element BALF bronchoalveolar lavage fluid b.i.d bis in die, twice a day COPD chronic obstructive pulmonary disease COX-2 cyclooxygenase 2 CQLQ Cough Quality of Life Questionnaire CRP -score clinical, radiologic and physiologic score DLCO diffusing capacity of the lungs for carbon monoxide DPI Diphenyleneiodonium EBC expired breath condensate ECM extracellular matrix EC-SOC extracellular SOD EGCG Epigallocatechin gallate ELF epithelial lining fluid EMT epithelial-to-mesenchymal transition eNOS endothelial NOS ERK extracellular signal-regulated kinase FEV forced expiratory volume FITC fluorescein isothiocyanate FVC forced vital capacity GCL glutamate cysteine ligases GCLC glutamate cysteine ligase catalytic subunit GCLM glutamate cysteine ligase modifier subunit GPx glutathione peroxidase GSH glutathione GSSG oxidized glutathione GST glutathione S-transferase HO-1 heme oxygenase I HSP heat shock protein IL interleuquin iNOS inducible NOS IPF idiopathic pulmonary fibrosis JNK c-Jun N-terminal kinase KEAP1 Kelch like-ECH-associated protein 1 LPS lipopolysaccharide MDA malondialdehyde MMP matrix metalloproteinase MPO myeloperoxidase MUC mucin NAC n-acetyl cysteine NF nuclear factor kappa beta nNOS neural NOS NO nitric oxide NOS nitric oxide synthase NOX NADPH oxidase NQO1 NADPH oxidoreductase I NRF2 nuclear factor erythroid 2-related factor 2 PFD pirfenidone PFS progression-free survival PrxII peroxiredoxin II Quer quercetin RNS reactive nitrogen species ROS reactive oxygen species Sal B Salvianolic acid B SF-36 36-Item Short Form Survey SFN sulforaphane SGRQ St

Funding This work was supported by the General Medical Research Projects from The Science and Technology Bureau of Xi'an City

(PubMed) Jappe U, Bonnekoh B, Hausen BM, Gollnick H