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Pharmacological agents, such as corticosteroids, PPAR agonists, and NF-B inhibitors, have been investigated for their ability to modulate macrophage function and polarization in COPD ( 3.2.2 Regulatory T cells Tregs maintain immune homeostasis suppressing excessive inflammation ( 3.3 Immune checkpoints in COPD Immune responses in COPD are modulated by immune checkpoints that can either inhibit or enhance inflammation ( 3.3.1 PD-1/PD-L1 pathway The PD-1/PD-L1 axis is critical for regulating immune responses during chronic inflammation characteristic of COPD ( 3.3.2 TIM-3 as a potential target TIM-3 is another checkpoint that negatively regulates T cell responses