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Nitroreductase increases menadione-mediated oxidative stress in Aspergillus nidulans

has served as a consultant for AstraZeneca, Alexion, Amgen, Bayer, Boehringer Ingelheim, Biocity Biopharmaceutics, Dimerix, Eli Lilly, Novartis, Novo Nordisk, Roche and Travere Therapeutics and has received grant support from AstraZeneca, Bayer, Boehringer Ingelheim, Janssen and Novo Nordisk

GSH was used as an exemplar product, as the heterogeneity in GSH content within yeast populations has been demonstrated and the regulation of GSH in yeast offers a framework for the selection system [3043]