is selenium is part of the glutathione peroxidase enzyme system

is selenium is part of the glutathione peroxidase enzyme system Glutathione peroxidase-1 and neuromodulation: Novel

Name: is selenium is part of the glutathione peroxidase enzyme system Glutathione peroxidase-1 and neuromodulation: Novel
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Glutathione peroxidase 1 and neuromodulation: Novel potentials of an old enzyme ScienceDirect Selenoneine inspired selenohydantoins with glutathione peroxidase like activity ScienceDirect Role of Selenium Dependent Glutathione Peroxidases (Seleno GPxs) in Radio Modulation: Lessons for Radiation Oncology Biological Trace Element Research Springer Nature Link Crystal structure and functional characterization of selenocysteine containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction ScienceDirect

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Description

Through this pathway, electrons are channeled from nicotinamide adenine dinucleotide phosphate (NADPH) to reduce hydrogen peroxide, with GSH as the rate-limiting step for regenerating NADPH [23,24]

GTP binds to the allosteric domain above the catalytic domain at the bottom of the antenna to block GDH catalytic activity and stop the release of glutamate oxidative products, which is a rate-limiting step