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Consequently, future research should focus on identifying precise therapeutic targets and characterizing the alterations in downstream signaling pathways, enabling berberine to exert a pivotal role in the treatment of DN by targeting these pathways

Numerous in vitro studies show that ITCs induce apoptosis via both intrinsic and extrinsic pathways (108)for instance, through caspase activation (109), mitochondrial dysfunction (110), and oxidative stress generation (111)

The mechanisms behind MOTS-c are fascinating, but the peptide has a notable lack of long-term safety data

Alice de Boyer des Roches (UMR Herbivores, INRAE) and Dr