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Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury

The cytochrome C-based pathway is the primary metabolic pathway for melatonin, and melatonin can be catalysed to form 6-hydroxymelatonin and 6-sulphatoxymelatonin ( 1 -actyl-N 2 -formal-5-methoxykynuramine (AFMK) and N 1 -acetyl-5-methoxykynuramine (AMK) ( 2.3 Uptake, synthesis and degradation of melatonin by mitochondria Melatonin is an amphiphilic molecule which can easily interact with the phospholipid bilayers and directly cross the cell membrane (Wang et al., 2011)