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Urinary Cytokeratin 20 Predicts Severe Acute Kidney Injury and Major Adverse Kidney Events in Adults Undergoing Cardiac Surgery

10.1016/j.envpol.2022.118959 96

doi: 10.12659/MSM.919195 29 Gonalves de AssisNRBatistoni de MoraisSFigueiredoBCRicciNDde AlmeidaLAda Silva PinheiroCet al

Overview of Senolytics Senolytics are a class of therapeutic agents specifically designed to eliminate senescent cells, which are cells that have entered an irreversible condition of cell cycle arrest while remaining metabolically active.36 Numerous stressors, such as telomere attrition, oxidative stress, DNA damage, and oncogene activation, induce cellular senescence.1 Initially, senescence safeguards against cancer by inhibiting the proliferation of damaged cells