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Targeted delivery of probiotics and their metabolites, based on the pathological link between intestinal microbiota metabolites and ferroptosis, may help inhibit ferroptosis, correct microbiota dysregulation, and restore immune homeostasis, offering a promising precision intervention strategy to alleviate IBD inflammation

Kovacic P, Sacman A, Wu-Weis M: Nephrotoxins: widespread role of oxidative stress and electron transfer

and Wahren, J

One mechanism involves the S-sulfhydation of OTU domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) at Cys91, which stabilizes the Xc light chain subunit (xCT), thereby promoting cystine uptake and maintaining GSH biosynthesis [77]