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Therefore, several international organizations, including the Food and Agriculture Organization (FAO), have begun publishing country-specific guidelines for antimicrobial use and raising awareness about this issue (Hegazy and Oreiby, 2024)

Bruceine A, a quassic ester from Bruceae Fructus, initiates autophagy as indicated by the upregulation of LC3I/II and ATG5 through targeting the PI3K-AKT pathway [173]