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Nat Rev Rheumatol (2020) 16:668

Some people get them once a week, while others might get them twice a week

A comprehensive economic analysis was conducted and revealed that all replacement levels provided superior margins compared to the control group, with optimum economic result for the 50% replacement in this case (Figure 3)

In response to signals such as IFN-, Toll-like receptor agonists, or IL-4/IL-13, macrophages can respectively enter classical activation (M1) or alternative activation (M2) states