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*Correspondence: Chaohua Deng, [email protected] Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Introduction Overview Pyruvate dehydrogenase complex deficiency is an inborn error of mitochondrial energy metabolism caused by partial or total inactivation of the mitochondrial matrix multienzyme pyruvate dehydrogenase complex

Given this relationship, evaluating the modulation of the FGF1/PI3K/Akt axis provides valuable insight into potential neuroprotective mechanisms