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We performed model calibration through parameter estimation and subsequently validated the model

Electrons leaking from the ETC can prematurely react with oxygen, resulting in the generation of reactive oxygen species (ROS)

Statistical analyses All data calculations and statistical analyses were performed using the R software ( version 4.2.2)

Daly AK, Donaldson PT, Bhatnagar P, Shen Y, PeEr I, Floratos A, Daly MJ, Goldstein DB, John S, Nelson MR, Graham J, Park BK, Dillon JF, Bernal W, Cordell HJ, Pirmohamed M, Aithal GP, Day CP (2009) HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin